The NPHS2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to NPHS2, NPHS2 podocin, and Podocin. This antibody recognizes Human, and Mouse antigen. The NPHS2 Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
This gene encodes the glomerular protein podocin which plays a role in the regulation of glomerular permeability, and acts as a linker between the plasma membrane and the cytoskeleton. Defects in this gene are the cause of autosomal recessive steroid-resistant nephrotic syndrome (SRN). SRN is characterized by onset between three months and five years, resistance to steroid therapy and rapid progression to end-stage renal disease. An alternative splice variant has been described but its full length sequence has not been determined